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December 16, 2014

special edition

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Welcome to US Autism & Asperger Association WeeklyNews, an e-mail newsletter that addresses a range of topics on autism, Asperger Syndrome, PDD, and other related disorders.

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A Mother's Aha Moment
A Compelling Story of Recovery

"It changed my life, because it showed me all the things medically wrong that could be causing my child to have autistic symptoms....once I started educating myself by coming to conferences, reading, e-mail, chat groups, I started getting the education I needed so that I could be that advocate for my child."

An excerpt from Lori-Knowles Jimenez presentation, "A Compelling Story of Recovery", on September 5, 2014 at the USAAA World Conference in Kansas City, Missouri, is posted on the USAAA YouTube Channel. The 9:47 minute video focuses on the recovery of her son Daniel, who is also interviewed by Lori. Other topics include getting help and advice, GFCF Diet, Gastrointestinal issues, Warning signs, Lab testing, Early intervention, plus more. View video.

"Lab testing was huge for me. That was my aha moment. When I got those lab tests and I looked at them and I saw all the abnormal levels, all the horrific gut bacteria that was in his gut, all the high levels of yeast, and I knew something was wrong."

For the complete video and all USAAA conference video downloads, visit

Access to USAAA Newsletter Archive 2005 - 2014

Gastrointestinal microbiota in children with autism in Slovakia

Tomova A, Husarova 2, Lakatosova S, Bakos J, Vlkova B, Babinska K, Ostatnikova D. 2015 Jan

Development of Autism Spectrum Disorders (ASD), including autism, is based on a combination of genetic predisposition and environmental factors. Recent data propose the etiopathogenetic role of intestinal microflora in autism. The aim of this study was to elucidate changes in fecal microbiota in children with autism and determine its role in the development of often present gastrointestinal (GI) disorders and possibly other manifestations of autism in Slovakia.

The fecal microbiota of autistic children showed a significant decrease of the Bacteroidetes/Firmicutes ratio and elevation of the amount of Lactobacillus spp. Our results also showed a trend in the incidence of elevated Desulfovibrio spp. in children with autism reaffirmed by a very strong association of the amount of Desulfovibrio spp. with the severity of autism in the Autism Diagnostic Interview (ADI) restricted/repetitive behavior subscale score.

Access to USAAA Newsletter Archive 2005 - 2014

The impact of microbiota on brain and behavior: mechanisms & therapeutic potential.

Borre YE1, Moloney RD, Clarke G, Dinan TG, Cryan JF. 2014

There is increasing evidence that host-microbe interactions play a key role in maintaining homeostasis. Alterations in gut microbial composition is associated with marked changes in behaviors relevant to mood, pain and cognition, establishing the critical importance of the bi-directional pathway of communication between the microbiota and the brain in health and disease.

Dysfunction of the microbiome-brain-gut axis has been implicated in stress-related disorders such as depression, anxiety and irritable bowel syndrome and neurodevelopmental disorders such as autism.

Access to USAAA Newsletter Archive 2005 - 2014

Gut microbiota and Parkinson's disease

Scheperjans F1, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E, Haapaniemi E, Kaakkola S, Eerola-Rautio J, Pohja M, Kinnunen E, Murros K, Auvinen P. 2014 Dec

In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently affected by alpha-synuclein pathology. Accordingly, gastrointestinal dysfunction, in particular constipation, is an important non-motor symptom in PD and often precedes the onset of motor symptoms by years.

Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and PD and the suitability of the microbiome as a biomarker. © 2014 International Parkinson and Movement Disorder Society.

These findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype.

Access to USAAA Newsletter Archive 2005 - 2014

Artificial Sweeteners Cause Glucose Intolerance by Altering Gut Microbiota

Reference: Suez J, et al. Nature. 2014;514:181-6.

In September 2014, investigators reported that non-caloric artificial sweeteners alter gut flora and promote glucose intolerance. According to the National Household Nutritional Survey 2004, 15% of the population regularly use artificial sweeteners. Consumer Reports stated that 65% of American households bought at least one sucralose-containing product in 2008.

The investigators also evaluated 381 non-diabetic subjects for artificial sweetener intake, blood sugar metabolism, and gut microbiota. The researches determined that the subjects who consumed the greatest amount of artificial sweeteners had higher fasting glucose levels, poorer glucose tolerance, and altered gut microbe profiles compared to the subjects that did not consume artificial sweeteners.

The researchers stated, "Collectively, our results link non-caloric artificial sweeteners consumption, dysbiosis, and metabolic abnormalities, thereby calling for a reassessment of massive non-caloric artificial sweeteners usage."

Access to USAAA Newsletter Archive 2005 - 2014



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